MedBalans

Diabetic foot infection — moderate–severe

Adults · verify locally

Inpatient

First line

  • Piperacillin/tazobactam · i.v.

    4.5 g IV q6–8h

  • Ampicillin/sulbactam · i.v.

    3 g IV q6h

Alternatives

  • Ceftriaxone + metronidazole (± MRSA agent) · i.v.

    Ceftriaxone 2 g daily + metro 500 mg IV tid ± vancomycin

  • Vancomycin + ciprofloxacin + metronidazole · i.v.

    Per weight/renal function

Duration

1–3 weeks soft tissue; longer if osteomyelitis after resection plan

  • • IWGDF / IDSA diabetic foot (2023)