MedBalans

Diverticulitis (inpatient / complicated)

Adults · verify locally

Inpatient

First line

  • Ceftriaxone + metronidazole · i.v.

    Ceftriaxone 1–2 g IV daily + metro 500 mg IV tid

Alternatives

  • Piperacillin/tazobactam · i.v.

    4.5 g IV q6–8h

  • Ertapenem · i.v.

    1 g IV daily

  • Ciprofloxacin + metronidazole · i.v.

    Cipro 400 mg IV bid + metro 500 mg IV tid

Duration

Until clinical improvement + short course after source control (often ~4–7 days total IV/PO)

Notes

  • Drain abscesses; operate for free perforation/peritonitis.
  • Step down to oral agents when stable.

Blood cultures if febrile/septic; drain/operative cultures.

  • • WSES diverticular disease (2020)